RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-27a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; dual-luciferase reporter assay etc.
Target
SP1;CDC42
Pathway
NA
PubMed ID
Title
"Nebivolol Induces Distinct Changes in Profibrosis MicroRNA Expression Compared With Atenolol, in Salt-Sensitive Hypertensive Rats"
Year
2013
Function
"Nebivolol, but not atenolol, prevented the decrease in miR-27a and -29a induced by high-salt. Nebivolol and atenolol equally attenuated the decrease in miR-133a. In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression."